Tildren 10ML Injection

Tildren Injection is a prescription bisphosphonate from Ceva used to treat lameness caused by Navicular Disease and Bone Spavin in horses. Each vial supplies 50 mg of tiludronic acid (as 56.91 mg disodium tiludronate) as a freeze-dried powder that is reconstituted and given by slow intravenous injection. By regulating overactive osteoclasts, Tildren Injection reduces the excessive bone resorption that drives these painful, bone-related lamenesses and helps restore normal bone remodelling.

Key benefits of Tildren

• Treats the cause, not just the pain — reduces bone resorption by inhibiting osteoclasts rather than only masking discomfort.
• Clinically studied — improvement in lameness was demonstrated in double-blind, placebo-controlled trials for both navicular disease and bone spavin.
• Targeted bone regulation — acts in areas of excessive bone resorption without a negative effect on bone formation or mineralisation at the recommended therapeutic dose.
• Anti-arthritic potential — in-vitro data show inhibition of cartilage-degrading enzymes.
• Clinic-ready presentation — supplied as 10 × 10 mL sterile glass vials of powder and solvent for reconstitution.

What is the active ingredient in Tildren Injection?

The active ingredient is tiludronic acid (as disodium tiludronate), a bisphosphonate that regulates osteoclasts. Each vial contains 50 mg of tiludronic acid (56.91 mg disodium tiludronate).

What is Tildren Injection used for?

Tildren Injection is indicated for the treatment of lameness associated with the bone changes seen in navicular disease and bone spavin in horses. Tiludronic acid belongs to the bisphosphonate class, a group of medicines that act on bone metabolism. Areas of reduced bone density caused by inappropriate bone resorption (“osteolysis”) are common to both conditions; by inhibiting osteoclast activity, the product helps correct this imbalance.

How is Tildren Injection given to horses?

Tildren Injection must be administered by, or under the direction of, a veterinarian because it is delivered intravenously. The Ceva export label describes a dose of 0.1 mg tiludronic acid per kg bodyweight once daily for 10 days by slow intravenous injection — approximately 10 mL (one vial) of reconstituted solution per 500 kg per day. Alternatively, the course may be given as a single intravenous infusion diluted into a 1-litre bag of 0.9% sodium chloride or 5% glucose and infused slowly over a minimum of 30 minutes through a catheter placed in the jugular vein.

Clinical improvement is generally seen over a number of weeks rather than immediately, reflecting the way bisphosphonates act on bone turnover. For independent background, see peer-reviewed review of tiludronate in the horse.

Is Tildren Injection used in camels?

No. The Ceva label and published clinical evidence for this product cover horses, and it is not indicated for camels. For joint or lameness support in camels, ask your veterinarian about appropriate options.

Which conditions does Tildren treat?

Tildren is used to treat lameness associated with navicular disease and bone spavin in horses, and has been used as part of the management of back pain linked to bony lesions of the spine.

Always reconstitute, dose and infuse exactly as stated on the product label and leaflet supplied with your pack, and follow your veterinarian’s instructions. Where the product is used for navicular disease and bone spavin, it is important to combine treatment with corrective farriery. Always consult the label for restraints, contraindications, precautions and side effects, and adhere to all local and racing regulations.

Browse more of our full camels and horses category page, and compare related options such as Pentosan Evolution Injection, Halo Injection sodium hyaluronate. Always read the product label and consult your veterinarian before use. This information does not replace professional veterinary advice.